Attrition in the Canadian Healthy Infant Longitudinal Development (CHILD) study

Methods CHILD is a study assessing the environmental impact on children’s health. The study includes 4 recruitment sites across Canada (Vancouver, Edmonton, Manitoba, and Toronto). Women enrolled while pregnant will be followed, along with their child for 5 years. Home assessments were done at 3 months, clinical assessments at 1, 3, and 5 years of age, and questionnaires are administered every 6 months. If a study participant withdraws, staff completes a one page questionnaire to determine reasons for withdrawal. The checklist incudes: no reason given, father not interested, family lacks time, family concern regarding privacy, expense to family, inconvenient to travel, complicated family situation, testing difficult, enrolled in another study, too many questionnaires, separation, personal health issue and others. Maternal factors included: history of asthma or food allergy, marital status, socioeconomic status (post secondary education, income), ethnic/ cultural group, being born in Canada, age, and stress measured by a Perceived Stress Scale. Results CHILD recruited 3628 participants at 4 sites (Vancouver 816, Edmonton 840, Manitoba 1107, and Toronto 865). Of the 316 participants withdrawn from the study, 149 were not eligible due to birth issues and 167 withdrew). Attrition rates for those 167 who declined further study were 4.5% (37/816) in Vancouver, 6.2% (52/840) in Edmonton, 2.3% (25/1107) in Manitoba, and 6.1% (53/ 865) in Toronto. Of the 167, further information is available only for 100. 81% (81/100) withdrew due to a lack of time, 17% (17/100) withdrew due to family issues, and 16% (16/100) due to other reasons, such as moving away, religions reason, etc. We compared 2698 participants with available data with 167 withdrawn active participants. Perceived stress was high in 99% withdrawn vs. 69% of active participants (p=0.02). Other important factors for withdrawing include single mother status (12% vs. 6%, p=0.03), maternal history of asthma (13% vs. 23%, p=0.03), and maternal food allergy (11% vs. 22%, p=0.009).